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Updated: May 29, 2025

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions
11:21

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions

Published on: August 30, 2024

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RECQ4-MUS81相互作用有助于端粒维持,这对罗斯蒙德-姆森综合征有影响

Raghib Ashraf1,2, Hana Polasek-Sedlackova1,3, Victoria Marini2

  • 1National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kamenice 5/A4, 625 00, Brno, Czech Republic.

Nature communications
|February 3, 2025
PubMed
概括

RECQ4-MUS81相互作用对于管理复制应激在困难的DNA区域,防止染色体分离错误和保持基因组稳定性至关重要. 它的破坏会导致染色体不稳定,这与罗斯蒙德-姆森综合征等疾病有关.

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