包利塔克塞尔载联聚合物纳米粒子的鼻内输送,用于向的大脑输送
Vishawambhar Deshmukh1, Mahaveer Narwade1, Kavita Rai Gajbhiye2
1Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth, Erandwane, Pune, 411038, India.
AAPS PharmSciTech
|February 3, 2025
概括
使用带有帕克利塔塞尔纳米颗粒的鼻到大脑输送,大脑中的药物度增加了5.6倍. 亚酸结合纳米颗粒显示了最小的鼻腔组织变化,这表明它是治疗大脑疾病的有希望的策略.
科学领域:
- 纳米技术 纳米技术
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 传统的血脑屏障穿越对大型药物分子来说是一个挑战.
- 纳米载体系统可以保护药物免受降解,并改善药物输送.
- 向的纳米载体通过特定的结合来增强生物可用性.
研究的目的:
- 为了开发帕克利塔塞尔 (PTX) 装载的甲酸 (AA) 结合聚烯酸 (PCL) 纳米颗粒 (NP) 进行鼻内注射.
- 评估开发的NP的物理化学性质,体外药物释放和体外药物动力学.
- 评估AA-PTX-PNPs在鼻腔粘膜上的安全性.
主要方法:
- 用溶剂蒸发方法制备聚合物纳米粒子 (PNPs).
- 特性包括颗粒大小,PDI,泽塔潜力,EE,DL和表面形态.
- 进行了体外药物释放和体外药物动力学研究.
主要成果:
- 优化PTX-PNPs的粒子大小为114.7nm,泽塔电位为-27.6mV,捕获效率为97.3%,药物负荷为35.3%.
- 在体外释放显示了一个双相模式,最初爆发,随后持续释放.
- 活体内研究表明,脑PTX度增加了5.6倍,鼻腔粘膜变化最小.
结论:
- 带有阿斯科布酸结合的帕克利塔塞尔的聚合纳米粒子 (AA-PTX-PNPs) 适用于鼻腔内注射.
- 这种纳米载体系统为治疗大脑疾病提供了一个有前途的策略.
- 这项研究强调了鼻到脑输送的潜力,可以提高药物在大脑中的生物可用性.
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