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补充剂对血液透析患者的影响:元分析
Qiu Cheng1, Dandan Fan1, Pengyu Chen1
1Department of Nephrology, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, No. 363, Section 3, Furong Avenue, Yongning Street, Wenjiang District, Chengdu, 610041, Sichuan, China.
International urology and nephrology
|February 3, 2025
概括
补充剂可以增加血液透析 (HD) 患者的水平. 然而,它不会显著影响人体质量指数,脂质或炎症标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养生物化学 营养生物化学
- 氧化压力研究研究 氧化压力研究
背景情况:
- 血液透析 (HD) 患者经常表现出高氧化应激和炎症,增加营养不良的风险.
- 降低的水平在HD患者中很常见,并且与氧化应激和炎症有关.
- 这项研究调查了在缓解HD患者这些疾病中的作用.
研究的目的:
- 进行一项元分析,评估补充剂对血液透析患者的影响.
- 评估对HD患者营养状况,炎症标志物和氧化应激的影响.
主要方法:
- 在PubMed,Embase,Cochrane图书馆和Web of Science进行了系统的文献搜索,寻找相关的随机对照试验 (RCT).
- 来自7个RCT的数据涉及2080名参与者 (组1029名,对照组1051名) 用Stata15.0.0分析了数据.
- 搜索包括到2024年9月31日发表的研究.
主要成果:
- 补充剂显著增加了HD患者的水平 (SMD = 2.83,95% CI [2.43,3.24]).
- 对于体重指数,甘油三,总胆固醇,LDL,HDL,C反应蛋白,费里丁,Hx-C反应蛋白或血红蛋白没有观察到统计学意义上的影响.
- 分析包括七个RCT,共2080名参与者.
结论:
- 补充剂有效地提高了血液透析患者的水平.
- 目前的证据表明,补充剂对HD患者的关键营养和炎症标志物没有显著影响.
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