月球和火星的重力改变了免疫细胞与内皮细胞在抛物线飞行中的相互作用
Yu Du1,2, Bing Han3, Katharina Biere3
1Key Laboratory of Microgravity (National Microgravity Laboratory), Center of Biomechanics and Bioengineering, and Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, 100190, Beijing, China.
NPJ microgravity
|February 3, 2025
概括
月球和火星的部分重力会影响免疫细胞的行为,减少它们对血管壁的粘附. 这种免疫失调在太空任务期间对宇航员健康构成风险.
科学领域:
- 太空生物学空间生物学
- 免疫学 免疫学 免疫学
- 细胞生理学 细胞生理学
背景情况:
- 人类太空探索任务的目标是月球和火星.
- 部分重力环境可能会损害宇航员的免疫功能.
研究的目的:
- 为了研究月球和火星引力对免疫细胞内皮细胞相互作用的影响.
- 评估免疫细胞粘附,表面分子表达和细胞骨在部分重力下的变化.
主要方法:
- 使用了带有 THP-1 细胞和 HUVEC 细胞层的流室系统.
- 在抛物线飞行期间模拟月球 (0.16g) 和火星 (0.38g) 重力.
- 在基底和TNF诱导的炎症条件下监测细胞行为.
主要成果:
- 增加了THP-1细胞漂浮速度,并且在部分重力下降了对HUVEC的粘附力.
- 在月球和火星的重力中,粘附标记 (Mac-1,ICAM-1) 的表达升高,因TNF而加剧.
- 在部分重力下的HUVEC中减少了F-actin网络和改变了细胞骨组织,由TNF加强.
结论:
- 部分重力改变了免疫细胞内皮的相互作用,与微重力效应有相似之处.
- 这些免疫失调的程度因引力水平而异,需要进一步研究.
相关概念视频
Acceleration due to Gravity on Other Planets
4.1K
The gravitational acceleration of an object near the Earth's surface is called the acceleration due to gravity. It can be measured by conducting simple experiments on Earth. However, such an experiment is impossible to conduct on the surface of other planets.
Astronomical observations are thus used to measure the acceleration due to gravity on other planets. This can be determined by observing the effect of a planet's gravity on objects close to it. The crucial factor that helps in this...
Astronomical observations are thus used to measure the acceleration due to gravity on other planets. This can be determined by observing the effect of a planet's gravity on objects close to it. The crucial factor that helps in this...
4.1K
Weightlessness
5.0K
When an object is dropped, it accelerates toward the center of the Earth. If the net external force on the object is its weight, it is said to be in free fall; that is, the only force acting on the object is gravity. Galileo was instrumental in showing that, in the absence of air resistance, all objects fall with the same acceleration g. However, when objects on the Earth fall downward, they are never truly in free fall, because there is always some upward resistance force from the air acting...
5.0K
Gravity between Spherical Bodies
8.2K
Newton's law of gravitation describes the gravitational force between any two point masses. However, for extended spherical objects like the Earth, the Moon, and other planets, the law holds with an assumption that masses of spherical objects are concentrated at their respective centers.
This assumption can be proved easily by showing that the expression for gravitational potential energy between a hollow sphere of mass (M) and a point mass (m) is the same as it would be for a pair of extended...
This assumption can be proved easily by showing that the expression for gravitational potential energy between a hollow sphere of mass (M) and a point mass (m) is the same as it would be for a pair of extended...
8.2K
Principle of Equivalence
2.2K
According to Albert Einstein (1897-1955), free-falling and feeling weightless are intrinsically linked. If a person were in free-fall under gravity, for example, diving towards the Earth from an airplane, they would feel completely weightless. Similarly, a person descending in a lift may feel partially weightless. Broadly speaking, it is assumed that an object in a uniform gravitational field and an object undergoing constant acceleration in the absence of gravity are under the same...
2.2K
Variation in Acceleration due to Gravity near the Earth's Surface
2.4K
An object's apparent weight is its weight measured by a spring balance at its location. It is different from its true weight, the force with which the Earth pulls it, because of the Earth's rotation. Mathematically, an object's apparent weight equals its true weight minus the centripetal force that keeps it in a circular motion along with the Earth's surface every 24 hours.
The difference between the true and apparent weights is proportional to the square of the Earth's...
The difference between the true and apparent weights is proportional to the square of the Earth's...
2.4K
Kepler's First Law of Planetary Motion
3.9K
In the early 17th century, German astronomer and mathematician Johannes Kepler postulated three laws for the motion of planets in the solar system. He formulated his first two laws based on the observations of his forebears, Nikolaus Copernicus and Tycho Brahe.
Polish astronomer Nikolaus Copernicus put forth a theory that stated a heliocentric model for the solar system. According to this heliocentric theory, all the planets, including Earth, orbit the Sun in circular orbits.
On the other hand,...
Polish astronomer Nikolaus Copernicus put forth a theory that stated a heliocentric model for the solar system. According to this heliocentric theory, all the planets, including Earth, orbit the Sun in circular orbits.
On the other hand,...
3.9K


