微塑料在已故人类大脑中的生物积累
Alexander J Nihart1, Marcus A Garcia1, Eliane El Hayek1
1Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences, Albuquerque, NM, USA.
Nature medicine
|February 3, 2025
概括
微塑料和纳米塑料 (MNP) 越来越多地被检测到人类器官,如大脑,肝脏和脏. 在2016年至2024年期间,度显著上升,在受痴呆症影响的大脑中发现的水平更高.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 人类健康 人类健康 人类健康
背景情况:
- 全球环境中的微塑料和纳米塑料 (MNP) 度正在上升,引发了人们对人类暴露和健康的担忧.
- 在各种人体组织中检测到MNP,因此需要强大的检测方法.
研究的目的:
- 在人类脏,肝脏和大脑组织中检测和量化微塑料和纳米塑料 (MNP).
- 调查影响MNP积累及其在不同器官和患者队列中的分布的因素.
主要方法:
- 采用了补充方法:热解气色谱-质谱,减弱总反射率-里埃变换红外光谱和电子显微镜与能量分散光谱.
- 分析了MNP的存在,聚合物组成和死体组织 (脏,肝脏,大脑) 中的度.
- 在不同的人口统计,时间点 (2016年与2024年) 和痴呆症诊断中比较了MNP度.
主要成果:
- 人类脏,肝脏和大脑组织中证实存在MNP,这些组织主要由聚乙烯组成.
- 大脑组织显示出更高的聚乙烯比例和纳米尺寸的碎片状碎片.
- 从2016年到2024年,MNP度在肝脏和大脑组织中显著增加.
- 在患有痴呆症的大脑中观察到MNP积累的增加,特别是在脑血管壁和免疫细胞中.
结论:
- 人体组织,特别是大脑,积累了微塑料和纳米塑料 (MNP).
- 有一个明显的时间趋势,即在人体组织中增加MNP度.
- 进一步的研究对于了解MNP暴露途径,清除和潜在的健康影响,特别是神经毒性至关重要.
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