在长期COVID患者中探索DNA甲基化,端粒长度,线粒体DNA和免疫功能
Andrea Polli1,2,3, Lode Godderis4,5, Dries S Martens6
1Department of Public Health and Primary Care, Centre for Environment & Health, KU Leuven, O&N5 Herestraat 49, Leuven, Belgium. andrea.polli@kuleuven.be.
BMC medicine
|February 3, 2025
概括
长期COVID影响了数以百万计的持续症状,如疲劳. 心脏标记物 (热素T) 和端粒缩短是长期COVID患者运动后不适和疲劳的关键预测因素.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 传染性疾病 传染性疾病
背景情况:
- 长期COVID影响全球估计有6500万,其特点是持续症状 (疲劳,睡眠问题,PEM,疼痛,认知问题) 持续超过3个月后SARS-CoV-2感染.
- 常见的长期COVID症状包括疲劳,睡眠障碍,运动后不适 (PEM),疼痛和认知困难.
研究的目的:
- 调查导致长期COVID发展的临床和生物因素.
- 为了确定长期COVID症状集群的潜在生物标志物.
主要方法:
- 一项前性纵向队列研究包括在2020年3月至2022年3月期间感染SARS-CoV-2的358名患者.
- 综合性评估包括临床评估 (问卷,6分钟步行测试) 和生物测量 (DNA甲基化,端粒长度,线粒体DNA拷贝数,细胞因子,托洛T).
主要成果:
- 在参与者中确定了六个主要的临床集群,其中35.4%属于至少一个.
- 最大的群体 (n=57) 包括经历PEM,疲劳,睡眠障碍和疼痛的患者.
- 升高的托罗邦素T水平和端粒缩短成为长期COVID和PEM疲劳症状的重要预测因素.
结论:
- 长期COVID是一种异质的疾病,具有不同的临床表现.
- 心脏参与 (热素T) 和端粒缩短可能是长期COVID中发展PEM疲劳症状的重要风险因素.
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