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Updated: May 29, 2025

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
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由胆固醇积累引起的细胞衰老是由APOE4和AD中的 lysosomal ABCA1介导的

Shaowei Wang1, Boyang Li1, Jie Li1

  • 1Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.

Molecular neurodegeneration
|February 3, 2025
PubMed
概括

胆固醇的积累驱动阿尔茨海默氏症 (AD) 中的大脑细胞衰老,通过影响ATP结合盒载体A1 (ABCA1) 贩运. 针对这种途径可能为AD提供新的治疗策略.

关键词:
在ABCA1中,ABCA1是ABCA1.阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.卡维奥林 - 1 - 一个洞穴.胆固醇 胆固醇 胆固醇lysosome 是一个溶解体.衰老是一种衰老.

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