改善西非的抗生素利用:通过系统审查和证据综合来加强干预措施
Eric S Donkor1, Abdul-Halim Osman2, Bill Clinton Aglomasa2
1Department of Medical Microbiology, University of Ghana Medical School, Accra, Ghana. esampane-donkor@ug.edu.gh.
Antimicrobial resistance and infection control
|February 3, 2025
概括
抗菌素耐药性是一个日益增长的威胁,特别是在西非. 这项研究强调,迫切需要更好的抗生素管理计划,以打击抗药性增加并改善整个地区的抗生素使用.
科学领域:
- 全球健康 全球健康
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗菌素耐药性 (AMR) 是一个关键的全球健康威胁,预计到2050年每年会导致1000万死亡.
- 西撒哈拉以南非洲地区面临高AMR死亡率,但缺乏对人类抗生素使用驱动因素的全面分析.
- 了解抗生素使用模式对于在高负担地区减轻AMR至关重要.
研究的目的:
- 对西非的抗生素使用和抗菌药物管理 (AMS) 进行系统审查和元分析.
- 确定与抗生素消费和处方实践相关的关键驱动因素和知识差距.
- 为政策和未来的研究提供有效的AMR制策略的信息.
主要方法:
- 在PubMed和Scopus (2000-2024) 中进行系统的文献搜索,重点关注抗生素使用的五个领域.
- 提取关于抗生素消费,处方适当性,使用指标,AMS干预措施和知识/态度的数据.
- 随机效应模型对抗生素消费的元分析以及对其他领域的描述性分析.
主要成果:
- 包括64篇文章,显示了抗生素消费的显著变化 (综合估计为620.03 DDD/100个睡眠日) 和处方适当性 (综合估计为50.09%).
- 通常消费的抗生素包括阿莫西西林, gentamicin 和阿莫西西林-clavulanate.
- 抗微生物药物管理干预措施的有效性各不相同;捆绑干预措施和决策支持工具是最具影响力的. 消费者和提供者之间普遍存在知识缺口和自我治疗.
结论:
- 在西非,有关抗生素使用的知识和实践存在重大差距.
- 对抗微生物药物管理计划的进一步实施和研究至关重要.
- 需要制定政策和有针对性的干预措施,以解决该地区抗生素耐药性的驱动因素.
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