对低剂量纳尔特雷克松用于慢性疼痛管理的评估
Alexa Spargo1, Lauren Gonser1, Brittany Faley1
1Department of Pharmacy, Kansas City Veterans Affairs Medical Center, Kansas City, Missouri, USA.
Journal of pain & palliative care pharmacotherapy
|February 4, 2025
概括
低剂量纳尔特雷 (LDN) 在患有慢性疼痛病的退伍军人中显示出适度的疼痛缓解. 虽然一般耐受性很好,但在其他治疗失败后,可以考虑LDN作为额外的疼痛控制.
科学领域:
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
- 临床研究 临床研究
背景情况:
- 纳尔特雷是FDA批准的酒精和阿片类药物使用障碍.
- 低剂量纳勒 (LDN) 越来越多地用于非标签的慢性疼痛疾病,如纤维肌痛和神经病变.
- 关于慢性疼痛的LDN现有研究通常涉及小样本大小和短的随访期.
研究的目的:
- 评估低剂量纳尔特雷在退伍军人慢性疼痛管理中的有效性和耐受性.
- 通过回顾性图表审查,评估LDN对退伍军人人口疼痛评分的影响.
主要方法:
- 退伍军人治疗慢性疼痛的低剂量纳尔特雷克松 (每天4.5毫克) 的退役军人的回顾性图表审查.
- 分析疼痛评分从治疗开始到最近一次临床访问的变化.
- 治疗持续时间和报告的不良反应的文件.
主要成果:
- 平均LDN治疗持续时间为123天,大约一半的退伍军人继续接受治疗.
- 观察到疼痛评分的平均小幅降低 (-0.83).
- 一般来说,LDN的耐受性很好,有32%的退伍军人报告了诸如生动梦,昏昏欲睡,头和恶心等不良影响.
结论:
- 低剂量纳尔特雷在退伍军人的慢性疼痛中表现出适度的减少.
- 一般来说,LDN的耐受性很好,这表明它具有良好的安全性.
- 经过风险-益处讨论,LDN可能是退伍军人未对多种先前疗法产生反应的额外疼痛控制的可行选择.
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