休息状态大脑活动的相似之处和差异 独特的慢性疼痛类型的变化
Xiaofei Chen1, Ruoyu Tang2,3, Yihan Jin1,2
1Department of Radiology, The Affiliated Hospital of Hangzhou Normal University, Zhejiang, Hangzhou, China.
Oral diseases
|February 4, 2025
概括
内脏和体质疼痛共享大脑活动模式,特别是在情感区域. 这些神经相似性可能作为疼痛障碍的生物标志物,如易怒肠综合征和关节障碍.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 疼痛研究 疼痛研究
背景情况:
- 慢性疼痛状况,如刺激性肠综合征 (IBS) 和部疾病 (TMD) 显著影响生活质量.
- 了解内脏 (IBS) 和体质 (TMD) 疼痛的神经支对于开发有效治疗方法至关重要.
研究的目的:
- 调查慢性内脏疼痛 (IBS) 和体质疼痛 (TMD) 患者之间自发大脑活动的神经相似性和差异.
- 用静止状态功能磁共振成像 (fMRI) 来比较IBS患者,TMD患者和健康对照 (HC) 的大脑活动模式.
主要方法:
- 休息状态的fMRI对28名IBS患者,21名TMD患者和28名HC患者进行了测试.
- 分析包括低频波动的幅度 (ALFF),区域同质性 (ReHo) 和功能连接性 (FC).
- 研究了fMRI指标和临床表现之间的相关性.
主要成果:
- 与HC相比,IBS和TMD患者在几个大脑区域都显示出ALFF和ReHo的增加,包括近海马环 (PHG) 和insula.
- 与IBS患者相比,TMD患者在中间上额头 (SFGmed) 和舌头中表现出ALFF和ReHo的独特模式.
- 两组患者在PHG和与胰岛相关的网络中表现出增强的FC,而IBS患者在PHG和轨道前皮层之间表现出更高的FC,与情绪和胃肠道症状相关.
结论:
- 大脑网络的共同异常突出显示了潜在的内脏和体质慢性疼痛的共同神经机制.
- 情感大脑区域的活性变化可能代表疼痛障碍的潜在神经成像标志物.
- 在身体疼痛中,抑郁症的严重程度与疼痛的强度有关,而在内脏疼痛中,它与胃肠道症状有关.
相关概念视频
01:25Analgesia and Pain Management
443
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
443
01:20Pain
443
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
443