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低血糖挑战测试结果作为早期儿童发育延迟的潜在风险因素:日本环境和儿童研究

Satoshi Shinohara¹, Reiji Kojima², Sanae Otawa³

¹Department of Obstetrics and Gynecology, Yamanashi Prefectural Central Hospital, 1-1-1 Fujimi, Kofu, Yamanashi 400-8506 Japan.

Journal of diabetes and metabolic disorders

|February 4, 2025

概括

低母体葡萄糖挑战测试 (GCT) 的结果与儿童的神经发育迟缓有关. 这项研究发现,在沟通,运动和解决问题的技能方面,风险更高,特别是在男性后代中.

科学领域:

产科和妇科产科和妇科
儿科神经学儿科神经学
发育儿科发育儿科

背景情况:

怀孕期间母亲的葡萄糖水平可能会影响胎儿的发育.
50克葡萄糖挑战测试 (GCT) 是一种常见的妊娠糖尿病查工具.
低GCT结果与后代神经发育之间的关联需要进一步澄清.

研究的目的:

研究母亲50克葡萄糖挑战测试 (GCT) 结果与3岁儿童神经发育结果之间的关系.
为了确定低于平均水平的GCT结果是否与后代早期神经发育延迟有关.

主要方法:

这是一项来自日本环境和儿童研究的12472名妇女的全国前性队列研究.
参与者被分为一个低GCT组 (≤10百分位数,≤81毫克/分升) 和一个非低GCT组 (82139毫克/分升),不包括那些妊娠糖尿病或GCT≥140毫克/分升.
使用多变量逻辑回归分析来评估低GCT结果与神经发育延迟之间的关联,使用年龄和阶段问卷,第三版.

主要成果:

与具有正常GCT结果的婴儿相比,具有低GCT结果的母亲的婴儿表现出神经发育延迟的发生率显著更高.
在沟通 (aOR 1.35),毛发动机 (aOR 1.31),细发动机 (aOR 1.26) 和解决问题的技能 (aOR 1.24) 方面注意到了具体的延迟.
在女性后代中没有发现任何显著的关联.

结论:

低母体50克葡萄糖挑战测试结果与3岁儿童的神经发育结果有关.
低GCT结果与神经发育迟缓之间的观察到的关联受后代的性别的影响.
这些发现强调了在评估儿童潜在的神经发育风险时考虑母体葡萄糖查结果的重要性.

关键词:

孕期糖尿病孕期糖尿病葡萄糖的挑战测试试验.低血糖症是什么意思低血糖症神经发育神经发育

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