血微RNA-145-5p作为急性深静脉血栓形成的诊断生物标志物
Christopher Antoun1, Vårin Eiriksdatter Wikan1, Øyvind Øverli2
1Thrombosis Research Group, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.
Research and practice in thrombosis and haemostasis
|February 4, 2025
概括
microRNA-145-5p (miR-145) 显示急性深静脉血栓症 (DVT) 的诊断性能不佳. 这项研究发现miR-145不适合作为诊断急诊室患者DVT的生物标志物.
科学领域:
- 发现生物标志物的发现.
- 分子诊断学 分子诊断学
- 血栓形成的研究研究
背景情况:
- 急性深静脉血栓 (DVT) 诊断通常依赖于成像.
- 需要新的生物标志物来提高诊断准确度,减少对成像的依赖.
- microRNA-145-5p (miR-145) 已被提议作为潜在的DVT生物标志物.
研究的目的:
- 评估血miR-145对急性下肢DVT的诊断性能.
- 在疑似DVT病例中,比较miR-145与D-二次体的诊断效用.
主要方法:
- 连续从急诊室招募了疑似急性DVT的患者.
- 血miR-145水平作为指数测试进行测量.
- 全腿压缩超声波作为DVT诊断的参考标准.
- 使用科恩的d效应大小和接收器操作曲线 (AUC) 下的面积来评估诊断性能.
主要成果:
- 在360名患者中,101名 (28%) 患有DVT.
- miR-145表现出较差的诊断性能 (AUC=0.59). miR-145显示出较差的诊断性能 (AUC=0.59).
- D-二元体显示出高的诊断性能 (AUC = 0.92).
结论:
- 血miR-145对急性下肢DVT的诊断性能不足.
- 在出现临床症状的患者中,miR-145不是诊断DVT的可靠生物标志物.
- 在这种临床环境中,D-二聚体仍然是对DVT诊断的优越生物标志物.
更多相关视频
相关概念视频
01:30Venous Thrombosis I: Introduction
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
01:29Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...