体质指数,高灵敏度C反应蛋白和抑郁症状之间的关联:NHANES 2015-2016年
Yan Zhang1, Fengya Zhen1, Yaxing Zhang1
1Department of Psychiatry, The First Hospital of Hebei Medical University, The Mental Health Center of Hebei Medical University, The Mental Health Institute of Hebei Medical University, Shijiazhuang, Hebei, China.
Frontiers in psychiatry
|February 4, 2025
概括
体重指数 (BMI) 和高敏感性C反应蛋白 (HSCRP) 是抑郁症状 (DP) 的危险因素. 这些关系是非线性的,取决于性别,在女性中观察到显著的关联.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 生物医学科学 生物医学科学
背景情况:
- 研究表明,身体质量指数 (BMI),高敏感性C反应蛋白 (HSCRP) 和抑郁症状 (DP) 之间存在联系.
- 这些相互关系的确切性质仍然不完全理解.
- 在全国代表性样本中进行全面检查是有必要的.
研究的目的:
- 调查BMI,HSCRP和DP之间的关联.
- 探索这些变量之间的潜在非线性关系.
- 检查这些协会中的性别特异性差异.
主要方法:
- 利用了2015-2016年国家健康和营养检查调查 (NHANES) 的数据.
- 使用患者健康问卷-9 (PHQ-9) 评估抑郁症状.
- 采用多变量逻辑回归,分层分析和通用添加模型来分析关系.
主要成果:
- 确定BMI (P=0.002) 和HSCRP (P=0.008) 是PD的危险因素.
- 在BMI和DP (P=0.035),BMI和HSCRP (P<0.001) 之间观察到非线性关系.
- 性别特定的研究结果显示,女性BMI和DP与HSCRP和DP之间存在显著的非线性关联,但男性并非如此. 报告指出,HSCRP与性别之间存在显著的相互作用.
结论:
- 无论是BMI还是HSCRP都是抑郁症状的确诊危险因素.
- BMI,HSCRP和DP之间的关系表现为非线性.
- 这些非线性关联取决于性别,在女性中更为明显.
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