战斗相关伤害后的侵袭性菌感染 - 一个回顾性队列研究
Tomer Hoffman1,2, Yael Haviv2,3, Amir Cohen2,3
1Infectious Diseases Unit, Sheba Medical Center, Ramat-Gan, Israel.
Mycoses
|February 4, 2025
概括
战斗伤口后的侵入性菌感染 (IMI) 是罕见但严重的. 马诺格皮克斯在体外表现出高活性,这表明治疗这些难以控制的感染的潜力.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 战斗医学 战斗医学
背景情况:
- 有限的数据存在于与战斗相关的伤口中的侵入性菌感染 (IMI).
- 了解这些感染对于改善伤员护理至关重要.
研究的目的:
- 描述近期冲突伤亡中IMI的临床特征和结果.
- 评估抗真菌敏感性,包括新药manogepix.
主要方法:
- 对受战伤和与伤口相关的IMI住院患者的回顾性研究.
- 对患者人口统计,损伤类型,IMI管理和结果的分析.
- 报告模具分离物,易感性测试和manogepix活动.
主要成果:
- 31名患者 (1.9%的发病率) 患有IMI,主要是由于爆炸伤害.
- 阿斯珀吉卢斯和Fusarium物种很常见,对醇和B.安福特素的不敏感性很高.
- 马诺格皮克斯在体外对大多数分离物有很好的活性,除了Mucorales.
结论:
- 与战斗伤口相关的IMI并不常见,但与显著的发病率和死亡率有关.
- 由于高度的易感率,Manogepix显示出有前途的结果.
- 需要进一步研究手术管理和抗真菌敏感性测试.
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