25氧维生素D状态和新脊椎骨折之间的关联 在绝经后患者皮肤穿脊椎增大后:一项回顾性病例对照研究
Shu-Bao Zhang1, Jin Yang2, Hao-Wei Xu1
1Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China; Department of Orthopedics, East Hospital, Ji'an Hospital, Jiangxi, People's Republic of China.
Pain physician
|February 4, 2025
概括
血清中25-基维生素D (25[OH]D) 含量低是绝经后妇女皮肤间脊椎增大后新脊椎骨折的危险因素. 补充剂可以降低折射风险.
科学领域:
- 整形外科 整形外科 整形外科
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
背景情况:
- 血清25-氧维生素D (25[OH]D) 缺乏与骨质疏松症和肌肉衰弱有关,增加了跌倒和骨折的风险.
- 低25[OH]D对绝经后女性皮肤穿透后脊椎增强 (PVA) 新脊椎骨折的影响尚不清楚.
研究的目的:
- 调查血清25[OH]D水平与PVA后骨质疏松性脊椎折断和级联脊椎骨折的风险之间的关联.
主要方法:
- 追溯病例控制研究涉及528名经更年期妇女 (>=50岁),她们接受了PVA.
- 患者根据骨折结果进行分组:非折断,骨质疏松性脊椎折断和级联脊椎骨折.
- 后勤回归和ROC曲线分析评估了25[OH]D水平的影响和预测值.
主要成果:
- 163名患者 (30.9%) 经历了新的脊椎骨折,包括124名 (23.5%) 骨质疏松性折断和39名 (7.4%) 级联骨折.
- 在新脊椎骨折的患者中观察到较低的血清25[OH]D水平.
- 升高的25[OH]D水平独立地与PVA后的折断和级联骨折风险降低有关.
- 25[OH]D水平显示了折断 (AUC=0.751) 和级联骨折 (AUC=0.831) 的预测值.
结论:
- 血清25[OH]D的低水平是绝经后妇女在PVA后出现新的脊椎骨折的独立危险因素.
- 在PVA后补充维生素D可以有效降低随后骨质疏松性脊椎骨折的风险.
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