相关实验视频

Updated: May 29, 2025

Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators
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Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators

Published on: November 27, 2015

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在胆化物/乙烯糖醇深度欧性溶剂中对不对称的交叉阿尔多尔碳聚合的计算洞察力

Yan Zhang1, Yong Sheng Yang2, Shi Jia Zhao1

  • 1College of Chemistry and Chemical Engineering, Neijiang Normal University, Neijiang, 641112, People's Republic of China.

Physical chemistry chemical physics : PCCP
|February 4, 2025
PubMed
概括

这项研究使用密度函数理论 (DFT) 来探索深度欧性溶剂 (DES) 中的交叉阿尔多尔反应. -COOH催化剂组和水添加增强了反应稳定性,有利于过程,与实验数据保持一致.

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Crossed Aldol Reactions: Overview01:04

Crossed Aldol Reactions: Overview

Crossed aldol addition is the reaction between two different carbonyl compounds under acidic or basic conditions. Here, both the carbonyl compounds function as nucleophiles and electrophiles. As shown in Figure 1, such a reaction yields a mixture of products, two of which are formed via self-condensation, while the remaining two are formed via crossed-condensation. Without adjustment, the reaction's usefulness in organic chemistry is decreased.
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This lesson deals with the crossed aldol reaction using weak bases. The self-condensation of an aldehyde having α hydrogen is prevented by adding it slowly to a mixture of formaldehyde and weak bases like hydroxide and alkoxide. Upon slow addition of the aldehyde, the base deprotonates the α carbon of the aldehyde to form the corresponding enolate. The enolate subsequently attacks the formaldehyde to form a single crossed product. Figure 1 depicts the aforementioned reaction.
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