SARS-CoV-2感染与动脉样硬化斑块进展的关联 在冠状动脉CT血管学和不良心血管事件中
Neng Dai1, Xianglin Tang1, Yiqing Hu1
1From the Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China (N.D., X.T., Y.H., H.L., Z.C., D.H., J.Q., J.G.); National Clinical Research Center for Interventional Medicine, 180 Fenglin Rd, Xuhui District, Shanghai 200032, China (N.D., X.T., Y.H., H.L., Z.C., D.H., J.Q., J.G.); GE HealthCare China, Shanghai, China (S.D.); Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China (W.G.); Shanghai Medical College, Fudan University, Shanghai, China (P.P.E.); and School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China (Y.Y.).
COVID-19加速冠状动脉斑块的进展,并增加高风险斑块的发生率. 由于这些变化,感染SARS-CoV-2的患者面临未来心血管事件的更高风险.
科学领域:
- 心血管成像 - 心血管成像
- 传染性疾病 传染性疾病
- 病理学 病理学 病理学
背景情况:
- 感染SARS-CoV-2 (导致COVID-19的病毒) 的患者面临心血管事件的风险增加.
- 导致感染后心血管风险增加的潜在机制尚未完全理解.
研究的目的:
- 为了研究SARS-CoV-2感染对冠状动脉炎症和斑块发育的影响.
- 评估SARS-CoV-2感染,冠状动脉斑块变化和临床心血管结果之间的关联.
主要方法:
- 从有或没有SARS-CoV-2感染的患者获得的连续冠状动脉CT血管学 (CCTA) 数据的回顾性分析.
- 数量评估斑块体积,组成 (动脉瘤体积百分比 - PAV),高风险斑块特征和周冠状腺脂肪组织 (PCAT) 衰减.
- 考克斯模型和日志级别测试被用来评估SARS-CoV-2感染和瘤失效之间的关系.
主要成果:
- 与对照人群相比,SARS-CoV-2感染患者的病变在整体PAV和非化PAV的进展显著加快.
- 在有SARS-CoV-2感染史的患者中,观察到患有高风险斑块特征和显著的PCAT衰减的更高发病率.
- 患有COVID-19的患者患有目标病变衰竭 (心脏死亡,心肌梗塞或再血管) 的风险明显更高.
结论:
- SARS-CoV-2 感染与冠状动脉斑块体积的加速进展以及发展高风险斑块的可能性增加有关.
- 患有COVID-19的个体的冠状动脉斑与不良心血管事件的风险增加有关,特别是向病变失败.
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