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Updated: May 29, 2025

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IL-23 促进干眼疾病进展中的gδT细胞活动

Yanxiao Li1,2, Zan Luo1,2, Zihao Liu1,2

  • 1State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, China.

Investigative ophthalmology & visual science
|February 4, 2025
PubMed
概括

结膜间白素-23 (IL-23) 通过增加 γδT 细胞和间白素-17A (IL-17A) 生产,驱动干眼病 (DED). 阻断IL-23受体 (IL-23R) 可能治疗DED炎症.

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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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