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Updated: May 29, 2025

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

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ARHGEF17/TEM4通过控制G1进展来调节细胞周期

Diogjena Katerina Prifti1,2,3, Annie Lauzier1,2,3, Chantal Garand1,2,3

  • 1Centre de Recherche du Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Axe de Réproduction, Santé de la Mère et de l'Enfant , Québec, Canada.

The Journal of cell biology
|February 4, 2025
PubMed
概括

关氨酸核酸交换因子ARHGEF17 (TEM4) 调节细胞循环的进展. 通过影响YAP和B循环蛋白的表达,TEM4的枯竭会导致线粒分裂和G1/S过渡的缺陷.

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The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
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Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
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Molecular Factors Affecting Cell Division

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Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
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