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Updated: May 29, 2025

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
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显型化病毒储存器,揭示HIV-1隐藏的地方

Wenxuan Chen1, Ben Berkhout1, Alexander O Pasternak2

  • 1Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Room K3-113B, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands.

Current HIV/AIDS reports
|February 4, 2025
PubMed
概括

识别HIV-1储存细胞是治愈HIV的关键. 虽然一些细胞标记物与病毒持久性有关,但没有任何单一标记物可靠地区分感染细胞,这阻碍了储库根除工作.

关键词:
艾滋病毒-1 治愈 治愈 治愈艾滋病毒-1 储备库多种组合的多种组合.现象类型分析分析储水池标记器是一个水库标记器.一个单细胞分析.

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Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
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