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一个基于Bi₂WO₆/BP异质连接的活性氧物种放大器,用于高效率的放射疗法增强

Shufen Ren¹, Qing Zhang¹, Hanping Fu¹

¹Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, Fujian-Taiwan Science and Technology Cooperation Base of Biomedical Materials and Tissue Engineering, Engineering Research Center of Industrial Biocatalysis, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, 350007, China. lqs671@163.com.

Journal of materials chemistry. B

|February 4, 2025

概括

这项研究引入了一种新的Bi2WO6-BP纳米平台,通过增加活性氧物种 (ROS) 和耗尽谷,改善瘤治疗来增强放射治疗. 纳米平台为多式联动癌症治疗提供了一个有前途的方法.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

放射治疗 (RT) 的疗效受到不足的活性氧物种 (ROS) 生成和瘤放射电阻的限制.
开发用于ROS诱导的亡和多式疗法的多功能放射敏感剂对于改善癌症治疗结果至关重要.

研究的目的:

设计和评估一个基于Bi2WO6-BP异质连接的新型多功能治疗纳米平台.
通过耗尽谷氨和放大ROS生成以改善放射治疗结果来增强协同瘤治疗.

主要方法:

制造一个Bi2WO6-BP异质连接纳米平台,利用高Z元素增强辐射剂量沉积.
研究X射线触发的催化过程在Z模式异质连接中,以放大ROS生成,特别是在低氧瘤微环境 (TME) 中.
探索Bi2WO6和黑 (BP) 纳米片 (NSs) 对单片氧 (1O2) 生产的协同效应,以及 (W) 氧化还原循环在酸性TME中的谷氨 (GSH) 消耗和ROS产生中的作用.

主要成果:

Bi2WO6-BP异质连接通过H2O2催化增加ROS生成并促进1O2生产,有效地增强了放射治疗.
该纳米平台通过W氧化还原循环证明了对TME敏感的谷氨耗尽,进一步增加了ROS水平.
在体外和体外的研究都证实了Bi2WO6-BP异构连接的高协同疗效,显示了深层瘤治疗的潜力.

结论:

开发的Bi2WO6-BP异质连接作为一种有效的多功能放射敏感剂.
这种纳米平台促进了TME触发的多式联动疗法,包括增强的ROS生成和谷氨耗尽.
该研究提出了一种可行的策略,以克服RT的局限性,并改善深度瘤治疗结果.

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