胰岛素抵抗替代品与绝经后妇女骨矿物质密度之间的关系
1Department of Endocrinology, Hebei Medical University Third Hospital, Shijiazhuang City, China.
Climacteric : the journal of the International Menopause Society
|February 4, 2025
概括
胰岛素耐药替代品,体重指数 (TyG-BMI) 和胰岛素耐药代谢得分 (METS-IR) 的甘油三糖,与较高的骨矿物质密度 (BMD) 有关,并可能保护中国绝经后妇女免受骨质疏松症 (OP).
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 代谢健康 代谢健康
背景情况:
- 胰岛素抵抗 (IR) 是一种代谢状况.
- 骨质疏松症 (OP) 是绝经后妇女的重大健康问题.
- 确定可靠的IR替代品对于评估骨健康至关重要.
研究的目的:
- 研究四种胰岛素抵抗 (IR) 替代品与骨矿物质密度 (BMD) 之间的关联.
- 确定IR替代品是否是中国非糖尿病绝经后患者骨质疏松症 (OP) 的风险因素.
主要方法:
- 计算了四种IR替代物:甘油三糖 (TyG),体重指数的TyG (TyG-BMI),甘油三/高密度脂蛋白胆固醇 (TG/HDL-C) 和胰岛素抵抗的代谢评分 (METS-IR).
- 使用双能X射线吸收计测量BMD.
- 采用了皮尔森相关性,后勤回归和接收器操作特征 (ROC) 曲线分析.
主要成果:
- 泰格-BMI和METS-IR与BMD有显著的积极关联.
- 增加的TyG-BMI和METS-IR与OP的流行率下降相关.
- 在对混因素进行调整后,TyG-BMI和METS-IR较高的四分位数显示,OP的几率显著降低.
结论:
- 替代IR的TyG-BMI和METS-IR与BMD有积极的关联.
- TyG-BMI和METS-IR可以作为中国非糖尿病绝经后妇女骨质疏松症的保护因素.
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