多参数MRI和转移学习用于预测乳房保护手术的积极利:一个多中心研究
Xue Zhao1,2,3, Jing-Wen Bai1,3, Sen Jiang4
1Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer & Xiamen Key Laboratory of Endocrine-Related Cancer Precision Medicine, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
International journal of surgery (London, England)
|February 4, 2025
概括
通过将多参数MRI (mpMRI) 与放射学和转移学习 (TL) 结合起来,可以提高预测乳房保护手术 (BCS) 的积极外科边缘. 这种方法可以提高跨不同患者数据集的预测准确性.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 准确预测积极的外科边缘对于成功的乳房保护手术 (BCS) 至关重要.
- 目前的方法可能缺乏为最佳的手术规划和患者结果所需的精度.
研究的目的:
- 开发和验证一个预测模型,用于BCS的积极的外科手术边缘.
- 评估多参数MRI (mpMRI) 与放射学和转移学习 (TL) 结合的疗效.
主要方法:
- 在多个中心对444名BCS患者进行了回顾性分析.
- 从mpMRI和临床病理学数据中提取和选择放射性特征.
- 机器学习分类器的应用与TL集成,用于增强模型通用化.
主要成果:
- 综合模型在内部 (0.889) 和验证 (0.771) 集中实现了高AUC值.
- 转移学习显著提高了外部验证集的预测准确性 (AUC为0.902和0.855).
- 综合方法在各种数据集中表现出强的性能.
结论:
- 通过转移学习增强的多参数核磁共振和放射学,为预测BCS中积极的外科边缘提供了强大的工具.
- 这种方法显示了改善多个机构的外科决策和临床应用的巨大潜力.
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