瓦索因希宾是由宁-血管素系统产生的
Francisco Freinet Núñez1, Lourdes Siqueiros-Marquez1, Elva Adán-Castro1
1Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), 76230 Querétaro, México.
Endocrinology
|February 4, 2025
概括
一种酶 - - 宁 (renin) 切割了前乳腺素 (prolactin,PRL),形成了血栓胺 (vasoinhibin),这是一种调节血管功能的激素片段. 这一发现揭示了氨酸-血管新生素系统在控制血管生长中的新作用.
科学领域:
- 生物化学 生物化学
- 内分泌学 在内分泌学.
- 血管生物学 血管生物学
背景情况:
- 瓦索因希宾是一种前素 (PRL) 片段,抑制血管生成,血管透性和血管扩张.
- 甲素D (CTSD) 之前被确定为一种蛋白酶,在新生小鼠视网膜中将PRL分裂为静脉阻尼素.
- 作为CTSD抑制剂的statin A也抑制了宁,这促使人们对宁在血管抑制素生成中的作用进行了调查.
研究的目的:
- 调查renin是否在新生小鼠视网膜和血液循环中切割前乳腺素 (PRL) 以产生血管抑制素.
- 探索氨酸- ангиотензин系统在调节血管生长和功能中的作用,通过血管inhibin.
主要方法:
- 对新生小鼠视网膜提取物进行分析,以使用蛋白酶抑制剂 (pepstatin A,VTP-27999) 和热无活化,将PRL切割为血管抑制素.
- 用各种PRL物种化复合氨酸以评估裂变.
- 在老鼠中通过脱水/再水和硫皮化物治疗诱导静脉阻素,然后用PRL进行血潜伏.
主要成果:
- 新生小鼠视网膜提取物将PRL切割为14kDa的静脉激素,这种活性被statin A抑制,并且是一种选择性宁抑制剂 (VTP-27999).
- 再组合雷宁直接从多种物种中切割PRL到14kDa的静脉阻尼素,与已识别的雷宁切割部位一致.
- 脱水/再水和硫皮化物治疗增加了循环PRL,并导致大鼠血中可检测的血管抑制素,由VTP-27999.9抑制.
结论:
- 列宁有助于从新生小鼠视网膜和循环中从益生菌素 (PRL) 生成血管阻素.
- 这些发现将氨酸识别为PRL分裂蛋白酶,并建议静脉胺作为氨酸-血管新生素系统调节的血管过程中的调解者.
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