基于多糖的自我愈合水凝用于pH诱导的酸的智能释放,以加速伤口愈合
Chelladurai Karthikeyan Balavigneswaran1, Manoj Kumar Sundaram1, Venkatesan Ramya2
1Tissue Engineering and Biomaterials Laboratory, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, Tamil Nadu, India.
ACS applied bio materials
|February 4, 2025
概括
由酸盐氧化碳甲基纤维素 (CS-o-CMC) 制成的注射用水凝可为伤口带提供自我愈合和受控释放. 这些响应pH的材料通过减少炎症和促进组织再生来加速伤口愈合.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 伤口愈合 治愈 伤口愈合
背景情况:
- 开发先进的伤口带对于有效的愈合至关重要.
- 现有的包裹往往缺乏对伤口微环境的反应.
- 可注射和自我愈合的材料提供了改善的治疗交付和整合.
研究的目的:
- 为创建一个pH响应的,可注射的,自我愈合的水凝用于伤口包裹应用.
- 为了研究从水凝中控制释放劳里克酸 (LA) 的情况.
- 评估开发的水凝的免疫调节作用和伤口愈合效果.
主要方法:
- 制造素氧化碳甲基纤维素 (CS-o-CMC) 水凝结构.
- 使用静电和希夫基形成进行凝,pH值通过β-甘油酸盐进行调整.
- 评估自我愈合特性,pH响应,劳里克酸释放动力学和M2极化调节.
- 在大鼠模型中评估伤口愈合,监测炎症,血管化和再上皮化.
主要成果:
- 成功制备了响应pH的CS-o-CMC水凝,具有自我愈合能力,在性条件下得到增强.
- 通过pH响应受劳里克酸 (LA) 受影响的受控释放.
- 显示M2极化调节,导致炎症减少.
- 在老鼠中观察到加速的伤口愈合,其特点是迅速的血管化和重新上皮化.
结论:
- 开发的CS-o-CMC水凝是一种有前途的可注射和自我愈合的伤口包裹.
- 它的pH响应性和免疫调节性质有助于有效的伤口愈合.
- 该战略为在具有挑战性的伤口环境中先进的伤口管理提供了一种新的方法.
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