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在腺瘤,瘤和正常肌肉膜中表达BCL6 (B细胞淋巴瘤6) 的表达

Loreta Canivilo Salas¹, Bruna Mielczarski², Raquel Camara Rivero¹

¹Postgraduate Program in Medicine, Surgical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

|February 4, 2025

概括

与正常组织相比,BCL6蛋白表达在子宫瘤中显著升高,但与腺瘤相比,没有显著升高. 这表明BCL6

科学领域:

妇科病理学的病理学
分子生物学分子生物学
生物医学成像学生物医学成像学

背景情况:

腺肌和乳腺瘤是常见的良性子宫疾病,涉及异常细胞生长.
转录抑制剂BCL6与细胞增殖和瘤发生有关,其在子宫内膜异位症中的作用已知.

研究的目的:

为了研究BCL6蛋白表达在腺瘤,瘤和正常肌肉.
评估深度学习神经网络在量化BCL6表达和分类子宫病理方面的实用性.

主要方法:

从子宫切除术 (2009-2017年) 中对氨酸嵌入子宫组织进行分析.
使用斐济图像J.使用BCL6表达量化的免疫组织化学.
监督深度学习神经网络用于基于DAB染色的样本分类.

主要成果:

形肌瘤的BCL6表达显著高于腺和正常肌肉肌瘤.
在腺和正常肌肉细胞之间没有发现BCL6表达的显著差异.
深度学习模型在分类样本方面取得了高精度,证实了免疫组织化学的发现.

结论:

BCL6蛋白可能在子宫乳腺瘤的发病过程中发挥作用,可能导致光滑肌肉细胞的增殖.
自动免疫组织化学和深度学习是量化子宫疾病中蛋白质表达的有效工具.
对BCL6在腺和子宫内膜异位症中的进一步研究是有必要的,以了解其在子宫疾病中的作用.

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