2型糖尿病,肥胖及其与甲状腺癌风险的关系
T Grimmichová1, V Kukliková, B Bulanová
1Institute of Endocrinology, Prague, Czech Republic. tgrimmichova@endo.cz.
Physiological research
|February 4, 2025
概括
2型糖尿病和肥胖不会增加甲状腺癌的风险. 然而,患有糖尿病的男性可能有较差的甲状腺癌结果. 糖尿病患者经常因为胰岛素抵抗而患上.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 代谢疾病 代谢疾病
背景情况:
- 2型糖尿病 (T2DM) 和肥胖与癌症风险增加有关,但与甲状腺癌的关联仍然不清楚.
- 关于T2DM,肥胖和甲状腺癌的现有研究尚未得出结论.
- 在T2DM中,胰岛素抵抗和高胰岛素血症可能会影响甲状腺健康.
研究的目的:
- 为了研究2型糖尿病,肥胖和甲状腺癌风险之间的联系.
- 为了评估糖尿病患者的甲状腺癌风险.
- 为了确定患有甲状腺癌预后改变的特定患者子组.
主要方法:
- 对184名患者进行了回顾性研究.
- 根据组织学,分类为恶性 (M),良性 (B) 和低风险癌症 (MB) 队列.
- 使用费舍尔精确测试和克鲁斯卡尔-瓦利斯ANOVA进行统计分析.
主要成果:
- 糖尿病患者表现出较大的甲状腺体体积与正常葡萄糖耐受度 (28.8vs17.6毫升) 的患者相比.
- 在瘤组织学队列中,没有发现年龄,BMI,血糖,HbA1c或HOMA-IR的显著差异.
- 男性患者,特别是糖尿病患者,表现出较高的远端转移发病率,微创性疾病,晚期阶段和TERT基因突变,表明预后较差.
结论:
- 2型糖尿病和肥胖并未被确定为甲状腺癌的危险因素.
- 糖尿病男性代表了一个潜在的甲状腺癌预后较差的亚组.
- 患有胰岛素耐药性和高胰岛素血症的糖尿病患者容易患上.
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