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在儿童骨折愈合期间维生素D水平
J Hendrych1, M Bayer, P Havránek
1Department of Pediatric and Trauma Surgery, Third Faculty of Medicine, Charles University, Thomayer Teaching Hospital, Prague, Czech Republic. jan.hendrych@ftn.cz.
Physiological research
|February 4, 2025
概括
维生素D缺乏症在骨折的儿童中很常见. 用维生素D3补充剂在愈合过程中显著改善了维生素D3水平,这凸显了儿童骨折患者检测和治疗的重要性.
科学领域:
- 儿科整形外科 儿科整形外科
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 维生素D在骨健康和骨折愈合中起着至关重要的作用.
- 儿童群体中维生素D缺乏和不足的患病率越来越令人担忧.
- 理想的维生素D水平对于儿童有效的骨修复至关重要.
研究的目的:
- 评估正在接受骨折治疗的儿童的维生素D水平.
- 评估维生素D补充剂对儿科患者骨折愈合的影响.
- 在儿童受伤时确定维生素D缺乏和不足的患病率.
主要方法:
- 这是一项为期四年的前性研究,涉及63名健康儿童,这些儿童患有半身骨或前臂骨折.
- 维生素D水平,以及P1NP,ALP,GGT和副激素,在受伤时和受伤后1,3个月和5个月被测量.
- 参与者被随机分为两个组:一个接受维生素D3补充剂,另一个没有.
主要成果:
- 在受伤时,42%的儿童缺乏维生素D,36.5%缺乏维生素D,21.5%的维生素D水平正常.
- 补充维生素D3的儿童在一个月内显示出维生素D水平在统计学上显著增加,这种增加是持续的.
- 补充维生素D的小组表现出更好的结果,无论最初的维生素D状况或骨折类型如何.
结论:
- 在患有骨折的健康儿童中,维生素D缺乏/不足的患病率很高.
- 维生素D3补充剂在一个月内有效地使儿科骨折患者的维生素D水平正常化.
- 常规维生素D测试和补充剂建议儿童治疗骨折,以支持最佳愈合.
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