功能性消化不良的口腔外口臭及其与小肠细菌过度生长的关联
Lei Yang1, Jing Jue Gong2, Xiao Ju Mo1
1Department of Stomatology, Minhang Hospital, Fudan University, Shanghai, People's Republic of China.
Journal of breath research
|February 4, 2025
概括
小肠细菌过度生长 (SIBO) 和功能性消化不良 (FD) 与外口臭有着密切的联系. SIBO,而不是H. pylori,是FD患者口臭发展的关键因素,而二甲基硫化物是主要的罪祸首.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 功能性消化不良 (FD) 经常与小肠细菌过度生长 (SIBO) 和口腔外口臭同时发生.
- FD,SIBO和口外口臭之间的关系需要进一步调查.
研究的目的:
- 调查小肠细菌过度生长 (SIBO),功能性消化不良 (FD) 和口外口臭之间的联系.
- 为了确定特定的挥发性硫化合物 (VSCs),有助于SIBO.在FD患者口臭.
主要方法:
- 使用感官分数 (OLS) 诊断口外口臭症.
- 评估FD总症状评分 (TSS),SIBO,Helicobacter pylori感染,以及呼出的VSCs (硫化,甲基,二甲基硫化).
- 统计分析包括赔率比率和曲线下的面积 (AUC) 以确定关联.
主要成果:
- 与非白症患者相比,白症患者的FD症状得分和SIBO阳性率显著更高.
- SIBO阳性比H. pylori感染更强烈地预测口腔外口臭 (OR=5.02).
- 硫化二甲基 (DMS) 被确定为与口臭相关的主要VSC,与FD症状严重程度有很强的相关性.
结论:
- 外口臭与功能性消化不良和小肠细菌过度生长密切相关.
- 在这种情况下,二甲基硫化物是导致口臭的主要挥发性硫化合物.
- 在FD患者中,SIBO是比H. pylori感染更重要的因素,在口外口臭的发展方面.
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