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细胞外囊泡在口服中应用和发展前景

Weiqun Li¹, Ming-Jie Dong², Zhaoqing Shi³

¹Longgang Central Hospital, Shenzhen, Guangdong 518116, People's Republic of China.

Biomedical materials (Bristol, England)

|February 4, 2025

概括

细胞外囊泡 (EVs) 提供了口服药物输送的自然解决方案,保护药物免受恶劣的胃肠道环境的影响. 本综述探讨了它们在纳米医学和制药应用中的潜力.

科学领域:

纳米医学是一种纳米医学.
细胞生物学细胞生物学
药物输送系统药物输送系统

背景情况:

细胞外囊泡 (EVs) 是基于脂的纳米级粒子,对细胞间通信至关重要.
口服是药物输送的理想途径,但由于胃肠道环境而面临生物可用性挑战.
电动汽车显示出克服这些障碍的潜力,作为治疗剂的自然载体.

研究的目的:

审查电动汽车的特性,分类和生产.
探索EVs在口服药物输送中的治疗疗效和潜力.
讨论EV在制药应用中的未来前景和挑战.

主要方法:

关于细胞外囊泡和口服药物输送的现有文献的综述.
分析与穿越生物障碍,特别是胃肠道相关的EV特性.
探索基于电动汽车的治疗应用和临床翻译挑战.

主要成果:

电动车具有独特的生物特性,使其成为口服药物输送的有希望的天然载体.
电动汽车可以潜在地保护各种药物 (,小分子,核酸,蛋白质) 免受降解.
通过口服,EV显示出在疾病预防和治疗方面的潜力.

结论:

细胞外囊泡代表了口腔纳米医学的重大进步.
进一步的研究和克服临床翻译挑战对于实现EV在药物输送中的全部潜力至关重要.
电动汽车为提高口服生物利用率和治疗疗效提供了一个有希望的平台.

关键词:

生物分布生物分布药物输送系统是药物输送系统.细胞外囊泡中的细胞外囊泡.胃肠道的胃肠道是什么样子的通过口服进行口服管理.

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