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在ESPINA研究中,PFAS和农药与从青春期到年轻成年期的肺功能变化之间的关联

Kayleigh Kornher¹, Carlos F Gould¹, Jomel Meeko Manzano¹

¹The Herbert Wertheim School of Public Health and Human Longevity Science, University of California, La Jolla, San Diego, CA, 92093, USA.

International journal of hygiene and environmental health

|February 4, 2025

概括

这项研究发现,常见的PFAS和农药对厄瓜多尔青少年肺功能没有显著影响. 需要进一步的研究来证实这些发现在更长的时间内在更大的人群中.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
肺部病理学肺部病理学

背景情况:

和多基基物质 (PFAS) 和农药是普遍存在的环境污染物.
接触这些化学物质与各种不良健康结果有关.
它们对青少年肺功能的具体影响,单独或作为混合物,尚不清楚.

研究的目的:

调查血清PFAS和尿路农药水平与青少年肺功能之间的关联.
检查单个化学物质暴露和化学混合物对肺功能的影响.
分析与环境污染物暴露有关的纵向肺功能数据.

主要方法:

厄瓜多尔381名青少年的长度队列研究 (2016-2022年).
测量了血清PFAS (PFOA,PFOS,PFNA) 和尿路农药 (草甘,2,4-D,ETU) 的含量.
评估了螺旋计肺功能,并使用了日志-日志模型和量子式g计算进行分析.

主要成果:

在单个或组合的PFAS和农药暴露和肺功能结果之间没有发现统计学意义上的关联.
对社会经济,地理和烟草暴露变量进行了调整.
对于PFOA,草甘和ETU,观察到FEV1/FVC的轻微,不显著的增加.

结论:

PFAS和农药,单独或组合,可能不会在这个特定人群中显著影响青少年肺功能.
研究结果表明,在中高海拔的农业环境中,影响有限.
建议在更大的队列和较长时间内进行进一步的研究.

关键词:

化学混合物化学混合物内分泌干扰化学物质可以破坏内分泌.持久性污染物持久性污染物螺旋测量是一种螺旋测量.年轻的成年人年轻的成年人

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