混合金属暴露对加快老龄化在老年人口中的健康影响
Chuanli Yang1, Jijun Zhang2, Haohan Liu3
1Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China; Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China; Key Laboratory of Environmental Medical Engineering and Education Ministry, School of Public Health, Southeast University, Nanjing, Jiangsu, China; Department of Preventive Medicine, School of Public Health, Southeast University, Nanjing, China.
接触重金属,特别是和,与老年人加速生物衰老有关. 这些发现强调了与环境毒素相关的潜在健康风险.
科学领域:
- 环境健康 环境健康
- 老年学是一门学科.
- 毒理学 毒理学 毒理学
背景情况:
- 人类通过各种日常途径接触重金属是很常见的.
- 混合重金属暴露对美国老年人口加速衰老的影响尚不清楚.
- 这项研究调查了重金属含量与加速衰老之间的联系.
研究的目的:
- 检查血液和尿液中的重金属度与加速衰老的发生之间的联系.
- 确定有助于加速衰老的特定重金属.
- 探索这些基于性别的关联中的差异.
主要方法:
- 分析血液 (n=2530) 和尿液 (n=716) 的金属度.
- 使用DNA甲基化数据计算GrimAge加速 (AgeAccelGrim).
- 应用加权多变量后勤回归和贝叶斯核机器回归 (BKMR) 来评估金属对金属的相互作用和单个金属对AgeAccelGrim的影响.
主要成果:
- 血液中的 (Cd) 与两性加速衰老的风险有显著的积极关联,尿路Cd的风险更高.
- 血 (Pb) 也与男性加速衰老风险的增加有关.
- BKMR确定是加速衰老的最重要贡献者.
结论:
- 个人和混合重金属暴露都与加速的生物衰老有关.
- 在重金属和加速衰老之间观察到的关联在男性中更为明显.
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