综合的多omics分析表明,CDC6是多种癌症类型的潜在预后和免疫治疗生物标志物,包括HCC
Chenxuan Li1, En-di Zhang1, Rui Yu1
1Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming 650032, Yunnnan, China.
Translational oncology
|February 4, 2025
概括
细胞分裂周期6 (CDC6) 在许多癌症中被上调,与预后不佳相关,并影响瘤进展. 降低调控的CDC6抑制肝细胞癌细胞生长和入侵,表明其作为癌症生物标志物和治疗点的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症基因组学 癌症基因组学
背景情况:
- 细胞分裂周期6 (CDC6) 是一种AAA+ ATPase,具有伴侣类活性.
- CDC6与各种癌症的发展和进展有关.
研究的目的:
- 研究CDC6在人类癌症中的表达和功能.
- 评估CDC6作为一种潜在的诊断和预后生物标志物.
- 探索CDC6在癌症免疫调节和向治疗中的作用.
主要方法:
- 使用TCGA,GTEx和HPA进行CDC6mRNA和蛋白质表达分析.
- 使用生物信息工具 (R,cBioPortal,UALCAN,SangerBox) 来分析CDC6在癌症中的作用.
- 进行了体外测试 (CCK-8,EDU,Transwell) 以评估CDC6对HCC细胞的淘汰效应.
主要成果:
- 在大多数癌症中,CDC6的调节升高,这与预后较差有关.
- CDC6的表达与免疫细胞透 (CD4+ Th2,MDSC) 和免疫调节基因相关.
- CDC6的表达与瘤突变负担 (TMB),微卫星不稳定性 (MSI) 和DNA/RNA变异有显著的相关性.
- 降低CDC6的调控抑制了HCC细胞的增殖,迁移和入侵.
结论:
- CDC6调节细胞循环,与多种癌症类型有关.
- 作为癌症诊断和预后的生物标志物,CDC6显示出有前途.
- CDC6可能是免疫调节和癌症治疗的目标.
更多相关视频
00:06An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
8.8K
12:24A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
5.1K
相关概念视频
02:40Cancer Stem Cells and Tumor Maintenance
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...