核转换改善了长期阻塞性肺部疾病肺和临床参数程度之间的相关性:一个多中心队列研究
Tai Joon An1, Youlim Kim2, Hyun Lee3
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
核转换提高了计算机断层扫描 (CT) 精度,用于慢性阻塞性肺病 (COPD) 中的肺评估. 这种标准化增强了肺气指数和COPD患者的关键临床措施之间的相关性.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 医学成像分析 医学成像分析
背景情况:
- 计算机断层扫描 (CT) 对于评估肺气至关重要,肺气是慢性阻塞性肺病 (COPD) 的关键表型.
- CT协议和设备的变化可能会损害肺瘤量化的准确性.
- 标准化CT图像分析对于可靠的COPD临床评估至关重要.
研究的目的:
- 在各种CT设置中实现内核转换,以对COPD患者的肺气评估.
- 评估核转换对肺瘤指数和临床参数之间的相关性的影响.
- 评估不同CT获取参数的肺瘤量化的一致性.
主要方法:
- 利用来自韩国COPD小组研究数据库的484名COPD患者的CT扫描图像.
- 通过深度学习将应用内核转换为CT图像,并使用%的低衰减区域 (%LAA-950) 来量化肺缩程度.
- 分析了%LAA-950和临床参数 (肺功能,mMRC,6MWD,CAT,SGRQ-c) 核转换前后之间的相关性.
主要成果:
- 内核转换显著降低了LAA-950值 (12.6±11.0到8.8±11.9) 的百分比变异.
- 在转换后,%LAA-950与FEV1 (r=-0.41),RV/TLC (r=0.42),mMRC (r=0.25),CAT (r=0.12),SGRQ-c (r=0.21) 和6MWD (r=0.15) 的相关性得到改善.
- 所有后核转换相关性都明显强于未转换数据集的相关性 (p<0.01).
结论:
- 核转换提高了基于CT的肺瘤定量在COPD的可靠性.
- 通过核转换进行标准化的CT图像处理,改善了肺气程度和临床结果之间的相关性.
- 这种方法提供了一种更一致的方法来评估肺气的严重程度及其对COPD患者的影响.
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