粉纳米颗粒调节大豆蛋白分离物的固体构成,以稳定高内部相位皮克林乳液用于黄素封装
Chengyi Sun1, Kai Du2, Zhijie Zhu1
1Key Laboratory of Jianghuai Agricultural Product Fine Processing and Resource Utilization of Ministry of Agriculture and Rural Affairs, Anhui Engineering Research Center for High Value Utilization of Characteristic Agricultural Products, College of Food and Nutrition, Anhui Agricultural University, Hefei 230036, China.
International journal of biological macromolecules
|February 4, 2025
概括
这项研究开发了使用粉纳米颗粒 (SNP) 和大豆蛋白分离物 (SPI) 复合物的高内部相皮克林乳液 (HIPEs),增强黄素封装和稳定性.
科学领域:
- 食品科学 食品科学 食品科学
- 材料科学 材料科学 材料科学
- 合体和表面化学
背景情况:
- 高内部相皮克林乳液 (HIPEs) 对于封装生物活性化合物至关重要.
- 稳定HIPE通常需要有效的接口代理来管理稳定性和功能.
- 粉纳米颗粒 (SNP) 和大豆蛋白分离物 (SPI) 具有作为天然乳化剂的潜力.
研究的目的:
- 通过调节SNP与SPI在油水界面上的复杂化来制造HIPE.
- 研究SNP-SPI复合体对乳液特性,稳定性和生物活性成分封装的影响.
- 为了评估SNP-SPI稳定HIPE在黄素封装和输送方面的性能.
主要方法:
- 在油水界面使用SNP-SPI复合体制造HIPE.
- 乳液性质的表征,包括乳液活性指数 (EAI) 和乳液稳定性指数 (ESI).
- 风病学测量,黄素封装效率和生物可访问性评估.
主要成果:
- 与单独的SPI相比,SNP-SPI复合体表现出优越的乳化特性.
- 通过SNP-SPI稳定的HIPE表现出增强的粘性弹性,凝状结构和改善的黄素封装 (83.1992.37%).
- 封装的黄素显示出更好的储存稳定性,热稳定性和增加的生物可访问性 (高达38.92%).
结论:
- SNPs-SPI复合有效地稳定HIPEs,通过增强双相可湿性和减少界面张力.
- 开发的HIPE为稳定和提供黄素等生物活性成分提供了一个有希望的系统.
- 这种方法为在食品和制药应用中利用SNP-SPI接口提供了基础.
相关概念视频
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
692
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
692
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
313
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
313


