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身体活动的时间,遗传倾向和发生抑郁症:基于加速仪的前性队列研究

Ge Tian¹, Zhi-Ying Yao¹, Wei Hu¹

¹Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Journal of affective disorders

|February 4, 2025

概括

早晨运动,特别是全身运动 (TPA),与抑郁症风险降低有关. 早上或下午进行中度至强度的体力活动 (MVPA) 也可以降低抑郁症的风险,特别是对于那些有遗传倾向的人来说.

科学领域:

流行病学流行病学
遗传学是一个遗传学.
行为科学行为科学

背景情况:

关于身体活动时间和抑郁症的前性队列研究很少.
了解遗传倾向如何影响这种关系至关重要.

研究的目的:

检查身体活动时间和发生抑郁症之间的关联.
调查遗传倾向是否会改变这些关联.

主要方法:

利用了来自76,218名参与者的英国生物库数据.
通过加速度计在7天内评估总体体力活动 (TPA) 和中度至强度体力活动 (MVPA).
采用Cox比例危险模型来确定危险比率 (HR) 和95%置信区间 (CI).

主要成果:

与中午下午活动相比,早晨的TPA与较低的抑郁风险 (HR:0.76) 有关.
早晨和中午下午的MVPA也显示了抑郁风险的降低 (HR:0.80和0.82,分别) 与不活动相比.
早晨TPA降低了不论遗传倾向的抑郁风险,但在具有高遗传倾向的人群中,好处最为明显.

结论:

早晨的TPA和早晨/中午的MVPA与较低的抑郁风险有关.
这些关联对于具有更高抑郁症遗传倾向的个体来说尤为重要.

关键词:

遗传倾向遗传倾向是一种遗传倾向.事件抑郁症是发生在一个人身上.身体活动的时间.

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