控制释放活性物质的微泡封装及其应用于乙氨基的口味掩饰
Albert T Poortinga1, Cornelus F van Nostrum2
1Department of Mechanical Engineering, Polymer Technology, Eindhoven University of Technology 5612 AZ Eindhoven, the Netherlands.
International journal of pharmaceutics
|February 4, 2025
概括
这项研究引入了一种新的微泡封装技术,用于控制小肠中药物释放. 该方法有效地掩盖了乙氨基的味道,并在模拟的肠道条件下确保药物快速释放.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 控制药物释放对于治疗疗效至关重要.
- 在液体配方中掩盖苦药的味道仍然是一个挑战.
- 微气泡封装为先进的药物输送提供了潜在的潜力.
研究的目的:
- 开发和描述一种新的微泡封装方法,用于控制药物释放.
- 评估乙氨基封装剂的口味掩饰和释放特性.
- 评估稳定性和适用于液体配方的适用性.
主要方法:
- 在微泡中使用固体-在-油-在-水乳液封装乙氨基.
- 经冷干燥制造出可溶解成微泡悬浮液的干粉.
- 在实验室测试稳定性,口味掩饰和药物释放在模拟的胃肠道液体.
主要成果:
- 达到90%以上的封装效率,在水溶液,唾液和胃汁中保持出色的稳定性.
- 已证明有效地掩盖了乙氨基的味道.
- 在模拟的肠液中展示了快速和几乎完全的药物释放.
结论:
- 开发的微泡封装方法提供了出色的屏障特性和触发释放.
- 该技术适用于液体配方中的口味掩饰和肠道释放应用.
- 这种方法有望改善药物的生物可用性和患者的遵从性.
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