评估眼部并发症和候选血病死亡率的预测因素:重复血培养是关键吗?
Hamail Iqbal1, Dejan Nikolic2, Carlo Foppiano Palacios3
1Cooper Medical School of Rowan University, Camden, New Jersey, 08103, USA.
Medical mycology
|February 4, 2025
概括
阳性后续血液培养 (FUBC) 不能预测候选血病中的眼部并发症. 然而,特定的Candida物种和视觉症状与眼部感染有关,而死亡率与其他因素如年龄和抗真菌疗程长度有关.
科学领域:
- 传染性疾病 传染性疾病
- 眼科医生 眼科 眼科
- 医学微生物学 医学微生物学
背景情况:
- 淋病症可能导致严重的眼部并发症,如内炎和胆炎.
- 眼科检查传统上是候选血病管理的一部分,但它们的普遍效用受到质疑.
- 识别眼参与候选血症的预后因素对于有针对性的管理至关重要.
研究的目的:
- 为了评估积极的随访血液培养 (FUBC) 和候选血病患者的眼睛参与之间的关联.
- 识别与眼球角膜炎相关的风险因素和临床指标.
- 为了确定在候选血病病例中医院死亡率的预测因素.
主要方法:
- 在一个学术医疗中心从2017年到2022年对238次白血病发作进行了回顾性审查.
- 收集的数据包括人口统计,风险因素,眼科检查结果,眼部感染和死亡结果.
- 统计分析涉及描述性统计,千二测试和多变量逻辑回归.
主要成果:
- 阳性FUBC和内炎或胆炎之间没有发现显著的关联.
- 眼部感染与视觉症状,Candida albicans,Candida dubliniensis和较长的抗真菌治疗有关.
- 医院死亡率与年龄较大,Candida lusitaniae,FUBC获取,眼科检查完成,血管压缩剂使用和较长的抗真菌治疗有关.
结论:
- 阳性FUBC不是眼球角膜炎的可靠指标.
- 特定的Candida物种 (例如,C. albicans,C. dubliniensis) 和视觉症状与眼部卷入有关.
- 需要进一步的研究来完善眼科评估的指示,并确定候选血症死亡风险因素.
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