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人母乳和支气管肺功能障碍有剂量依赖的效果:一个队列研究

Jiaming Yang^1,2, Jiaxin Li², Huiyan Wang³

¹Peking University Cancer Hospital (Inner Mongolia Campus), Hohhot, Inner Mongolia, China.

BMJ paediatrics open

|February 4, 2025

概括

较高的母乳 (HM) 量显著降低了出生时体重非常低的婴儿患支气管肺功能障碍 (BPD) 的风险. 确保足够的HM摄入量对于预防混合食方案中的BPD至关重要.

科学领域:

新生儿医学新生儿医学
儿童营养学儿童营养学
呼吸系统健康呼吸系统健康

背景情况:

人类母乳 (HM) 已因其对支气管肺功能障碍 (BPD) 的保护作用而得到认可.
在混合养中预防BPD的最佳HM体积尚未确定.
这项研究调查了HM体积和BPD风险之间的关系.

研究的目的:

为了确定不同人乳量对支气管肺功能障碍症 (BPD) 发生率的影响.
确定与降低出生体重非常低的婴儿BPD风险相关的母乳摄入的潜在门.

主要方法:

对339名出生时体重非常低 (VLBW) 的婴儿进行了回顾性队列研究.
分析母乳量与BPD风险之间的关联.
剂量依赖性分析使用线平滑,物流回归和灵敏度分析.

主要成果:

较高的HM体积 (≥1190毫升) 与较低的HM体积 (<1190毫升,27.0%) 相比,与明显较低的BPD发病率 (4.7%) 相关.
独家配方组的BPD发病率为9.1%.
在敏感性分析中,低HM体积被确定为BPD的危险因素 (OR 3.26-3.28).

结论:

较大的母乳量 (≥1190毫升) 与支气管肺功能失调风险降低有关.
低人乳摄入量可能会增加BPD发病率,而不是独家配方养,虽然在本研究中没有统计学意义.
人母乳的数量是VLBW婴儿混合养策略的一个重要因素,以减轻BPD风险.

关键词:

新生儿科学新生儿科学护理护理护理

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