患有视神经炎或骨髓灰质炎的患者的肠道微生物概况
Tao Wu1, Hanqiu Jiang2, Chen Lin1
1Department of Clinical Nutrition, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
The Journal of international medical research
|February 4, 2025
概括
与健康个体相比,患有视神经炎 (ON) 和肌痛神经炎 (MG) 的患者表现出改变的肠道微生物群,有益的肠道益生菌显著减少.
科学领域:
- 微生物组研究的研究.
- 神经免疫学 神经免疫学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群在免疫系统调节中起着至关重要的作用.
- 肠道微生物组成的改变与各种自身免疫和神经系统疾病有关.
- 视神经炎 (ON) 和肌痛神经炎 (MG) 是一种免疫媒介疾病,可能会影响肠-大脑轴.
研究的目的:
- 在被诊断为ON或MG的患者中调查和描述肠道微生物组成.
- 为了比较ON和MG患者的肠道微生物群形状与健康对照的肠道微生物群形状.
- 确定与ON和MG相关的特定微生物种群.
主要方法:
- 从45名ON患者,13名MG患者和20名健康对照人群收集了便样本.
- 细菌16S rRNA基因测序 (V3-V4区域) 在提取的微生物DNA上进行.
- 生物信息分析,包括多样性指标和LEfSe,用于比较微生物群落.
主要成果:
- 在患者组和健康对照组之间观察到肠道微生物群的明显聚类.
- 关键类 (Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria) 在不同群体中显示出不同的比例.
- 患有ON和MG的患者表现出有益益生菌的丰度降低,例如Bifidobacterium, Bacteroides和Roseburia.
结论:
- 在患有ON和MG的患者中,肠道微生物组成的显著变化是明显的.
- 在这些患者群体中,关键肠道益生菌的显著减少是这些患者群体的特征发现.
- 这些发现凸显了肠道微生物群在ON和MG的发病或进展中的潜在作用.
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