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乳腺的状细胞癌类似于伪血管瘤性流体增生症

Andrew H S Lee¹, Anne-Marie O'Shea^2,3, Ian O Ellis²

¹Histopathology Department, Nottingham University Hospitals NHS Trust - City Hospital Campus, Nottingham, UK andrew.lee@doctors.org.uk.

Journal of clinical pathology

|February 4, 2025

概括

这项研究确定了一种罕见的乳腺癌亚型 - - 脊柱细胞癌,它模仿了伪血管瘤性流体增生症 (PASH). 这种相似性构成了诊断挑战,特别是在核心活检中,可能导致对良性PASH的误诊.

科学领域:

在瘤学瘤学.
病理学病理学病理学
乳腺癌研究研究乳腺癌研究

背景情况:

伪血管瘤性胸膜增生症 (PASH) 是一种良性乳腺疾病,通常与妇产不良,纤维细胞损伤和纤维囊变化有关.
乳腺状细胞癌是一种罕见的恶性瘤,具有多种组织学表现.
之前没有报道过模仿PASH的状细胞癌的特定组织学模式.

研究的目的:

描述一系列的五种乳腺脊柱细胞癌,表现出类似于PASH的组织学模式.
为了突出这一前所未闻的乳腺病理学诊断陷.
帮助准确诊断这些罕见的恶性瘤.

主要方法:

对5例乳腺脊柱细胞癌的组织病理学审查.
对细胞克拉丁表达的免疫组合化学分析.
形态特征与典型的PASH和类似纤维素瘤的状细胞癌的比较.

主要成果:

这五个病例都呈现出类似PASH的状细胞形态.
这些瘤表现出平淡的细胞核,类似于纤维素瘤样状细胞癌.
在两例病例中,就在现场显示出相关的管道癌.
免疫组织化学检查在所有病例中都证实了细胞激素阳性.
类似PASH的外观是一个主要的特征,更多的细胞区域是焦点.

结论:

乳腺脊柱细胞癌很少能模仿PASH,这代表着一个重大的诊断挑战.
这种相似性在核心活检中尤其有问题,因为细胞区域可能是焦点.
准确的区分需要仔细的本病学评估和免疫组织化学的考虑.
识别这种模式对于避免误诊和确保适当的患者管理至关重要.

关键词:

乳房是最重要的.这是一种癌症,Carcinoma.免疫组织化学免疫组织化学

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