大型抑郁症患者的呼吸道疾病:系统性审查和元分析
Ana Jiménez-Peinado1,2,3, David Laguna-Muñoz1,2,3, María José Jaén-Moreno1,2,3
1Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.
概括
重度抑郁症 (MDD) 显著增加了呼吸系统疾病 (如喘和COPD) 的风险. 这种情况与这些疾病的发病率更高有关,特别是在女性和年轻人中.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 大型抑郁症 (MDD) 与预期寿命的缩短有关,呼吸系统疾病构成重大威胁.
- 关于MDD患者呼吸系统疾病患病率的现有证据尚未被系统地进行元分析.
研究的目的:
- 在患有MDD和耐治疗抑郁症 (TRD) 的患者中对呼吸系统疾病的患病率进行元分析.
- 为了确定与对照组相比,MDD和TRD患者的呼吸系统疾病的几率比率 (OR).
主要方法:
- 进行了系统的文献搜索和雪球搜索,以确定相关研究.
- 纳入标准集中在MDD和TRD患者的研究中,这些患者有确定的呼吸道诊断 (喘,COPD,肺炎,肺癌,结核病).
- 分析了15项研究的数据,包括超过476,927名MDD患者和1,108,979名对照.
主要成果:
- 患有MDD的患者显示COPD患病率为9.0%,喘患病率为8.6%.
- 与普通人群相比,患有MDD的个体的COPD发病率明显高 (OR1.79),年轻人 (OR1.85) 和女性的发病率甚至更高.
- 在MDD患者中,喘患病率是全球平均水平的两倍.
结论:
- MDD与呼吸系统疾病的风险增加有关.
- 女性和患有多重抑郁症的年轻人特别容易患上COPD.
- 建议紧急制定预防政策,以应对MDD患者呼吸系统疾病风险增加的问题.
相关概念视频
Depressive Disorders: MDD and Dysthymia
40
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
40
Depression: Overview
210
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
210
Depressive Disorders: Etiology
34
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
34
Common Respiratory Disorders
210
Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
210
Antidepressant Drugs: MAOIs and Other Agents
183
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
183
Stress and Mental Health
71
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
71


