基因捕捉和氧化物分解的泽醇抗氧化剂与潜在的生物应用对抗氧化应激
Manisha Yadav1, Nikhil Sodhi1, Palak Sethi1
1Department of Chemistry & Centre of Advanced Studies in Chemistry, Panjab University, Sector-14, Chandigarh, 160 014, India.
Chembiochem : a European journal of chemical biology
|February 4, 2025
概括
新的类二二醇具有显著的抗氧化和抗菌特性. 这些化合物显示出对抗细菌生长,生物膜形成,甚至三阴性乳腺癌细胞的有希望.
科学领域:
- 有机化学 有机化学
- 药用化学 医学化学
- 生物化学 生物化学
背景情况:
- 基索醇是具有潜在生物活性的一类化合物.
- 了解它们的抗氧化和抗微生物机制对于开发新的治疗剂至关重要.
研究的目的:
- 为了合成新型的基索醇.
- 为了评估它们的类似谷氨过氧化酶 (GPx) 的抗氧化活性.
- 评估它们的基因捕获抗氧化剂 (RTA) 能力,抗微生物,抗生物膜和细胞毒性作用.
主要方法:
- 从disenides和aldehydes中合成类二二醇.
- 使用硫醇进行氨酸过氧化酶 (GPx) 类活性测定.
- 基因捕捉抗氧化剂 (RTA) 活性通过在自氧化过程中的O2消耗来评估.
- 抗微生物和抗生物膜活性测试对细菌细菌和Pseudomonas aeruginosa.
- 在MTT试验中对MDA-MB-231乳腺癌细胞进行体外细胞毒性评估.
- 分子对接和动力学模拟以研究蛋白质-抗氧化剂相互作用.
主要成果:
- 合成的基索醇显示出类似GPx的抗氧化活性.
- 化合物13c显著抑制了氧化 (静态度因子n 2.2).
- 化合物对B. subtilis和P. aeruginosa表现出抗菌活性,具有抗生物膜潜力.
- 对MDA-MB-231细胞系观察到细胞毒性.
- 分子建模提供了与细菌标蛋白相互作用的见解.
结论:
- 基索醇是有效的抗氧化剂,具有抗微生物和抗生物膜的特性.
- 替代模式影响激素捕捉抗氧化活性.
- 这些化合物显示出对抗细菌感染和三阴性乳腺癌的治疗应用的潜力.
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