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Updated: May 29, 2025

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以EZH2为媒介的PHF10抑制放大了HMGB1/NF-κB轴,使胆管癌的化疗耐药性得到改善

Qiushi Yin1,2, Daning Lin1,2, Weiqian Zeng1

  • 1Department of Hepatobiliary Pancreatic Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, China.

Journal of cellular and molecular medicine
|February 4, 2025
PubMed
概括

在胆管癌 (CHOL) 中,PHF10 作为瘤抑制剂,抑制细胞生长和化学抵抗. 针对HMGB1,一个关键的下游效应因子,可以恢复PHF10低的CHOL瘤的化疗敏感性.

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