通过简单的方法测量尿液中的万科米辛度来预测曲线下的面积
Yuki Oshima1, Miyu Matsumoto2, Sumika Munakata2
1Division of Bioanalytical Chemistry, Department of Pharmaceutical Sciences, Showa University Graduate School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8555, Japan.
测量尿液中的万科米辛 (VCM) 水平提供了一种更简单的方法来监测药物水平. 这种方法可以帮助预测曲线下的面积 (AUC),以更好地给定万科米辛剂量,减少患者和医疗保健负担.
科学领域:
- 药理学 药理学是指药理学的学科.
- 分析化学 分析化学
- 临床药房 临床药房
背景情况:
- 治疗药物监测 (TDM) 的万科米辛 (VCM) 对于优化患者的结果至关重要.
- 目前用于VCM TDM的方法,特别是计算曲线下的面积 (AUC),涉及频繁取血样,增加成本和患者负担.
- 需要更简单,更少的侵入性方法来治疗VCM TDM.
研究的目的:
- 开发和验证一种用于测量尿液VCM水平的快速方法.
- 评估使用尿液VCM度来预测VCM AUC的可行性.
- 为了减轻与传统的VCM TDM相关的负担.
主要方法:
- 开发一种使用固相提取和光谱法进行尿液VCM量化的方法.
- 验证方法的准确性,精度和量化范围.
- 分析尿液VCM度趋势与接受VCM的患者的AUC相关.
主要成果:
- 开发的方法显示了100-2,000μg/mL的量化范围,准确度很高 (100.0%-108.5%).
- 日内和日间相对标准偏差分别低于3.39%和4.48%,表明精度很好.
- 在尿液VCM度和AUC的斜率之间观察到负相关性 (r=0.65),表明具有预测潜力.
结论:
- 成功开发了一种简单快速的方法来测量尿液VCM水平.
- 尿液VCM度趋势显示了预测VCMAUC的潜力,促进了AUC引导的TDM.
- 使用尿样的这种方法可以导致更合适的万科米辛治疗和减少医疗保健工作量.
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