基于Eudragit® RL和相反电荷的Eudragit®多元离子的Interpolyelectrolyte复合物的表征,作为用于结肠特定药物输送的新型矩阵系统
Rouslan I Moustafine1,2, Natalia N Porfiryeva3, Shamil F Nasibullin3
1Institute of Pharmacy, Kazan State Medical University, 16 Fatykh Amirkhan Street, 420126, Kazan, Russian Federation. ruslan.mustafin@kazangmu.ru.
新的介聚电解质复合物 (IPEC) 使用Eudragit®聚合物设计,用于潜在的结肠特异性药物输送. 这些pH敏感复合物显示出受控释放的印米他辛,这表明有望针对性治疗应用.
科学领域:
- 聚合物科学 聚合物科学
- 材料科学 材料科学 材料科学
- 制药技术 制药技术 制药技术
背景情况:
- 互聚电解质复合物 (IPEC) 为药物输送提供可调节的特性.
- 欧德拉吉特®聚合物在制药配方中广泛使用.
研究的目的:
- 设计和描述Eudragit®多离子 (RL) 和各种Eudragit®多离子 (L100-55,L100,S100,FS) 之间的新型互聚电解质复合物 (IPEC).
- 评估这些IPEC在结肠特异性药物输送应用中的潜力.
主要方法:
- 对IPEC形成和组成进行重力测量和元素分析.
- 福里埃变换红外光谱 (FTIR) 和调制温度差扫描热量计 (mDSC) 用于结构和固态分析.
- 胀研究和体外药物释放测定使用印米他作为模型药物.
主要成果:
- 成功合成了新型IPEC,其结合比率取决于聚离子碳酸组含量.
- 由于静电相互作用,观察到玻璃过渡温度的显著变化.
- 在酸性和中性介质中,IPEC表现出相当大的pH敏感膨胀.
- 药物释放研究表明,印梅他辛的输送受到控制.
结论:
- 设计的基于Eudragit®的IPEC具有pH敏感的胀和受控的药物释放特性.
- 这些IPEC显示出开发结肠特异性药物输送系统的巨大潜力.
- 进一步的研究可以优化这些复合物,以提高治疗效果.
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