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白细胞特征和肺癌风险:一个两样本的门德尔随机化分析分析
Kaijun Long1, Zhengfeng Zhu1, Xinzhe Zheng1
1Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, 563000, Guizhou, China.
Scientific reports
|February 5, 2025
概括
增加的总白细胞 (WBC) 计数和更高的单细胞计数与增加肺腺癌 (LUAD) 风险有因果关系. 这项门德尔的随机化研究强调了单细胞.
科学领域:
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 白血细胞 (WBC) 计数与各种健康结果有关.
- 了解白细胞计数和肺癌风险之间的因果关系对于早期检测和预防至关重要.
研究的目的:
- 使用孟德尔随机化 (MR) 调查总和亚型白细胞计数与肺癌风险,包括其亚型之间的潜在因果关系.
主要方法:
- 使用全基因组关联研究 (GWAS) 的总结统计数据进行了两样MR分析,用于WBC亚型 (乙酸性,中性,淋巴细胞,单细胞,基酸性,总WBC) 和肺癌 (包括LUAD,LSCC,SCLC).
- 标准MR方法包括反变量加权 (IVW),加权中位数,MR-Egger回归和MR-PRESSO被用于评估因果关系.
- 使用了包括29,266例肺癌病例和56,450例对照病例在内的大型GWAS数据集.
主要成果:
- 发现总白细胞 (WBC) 数量升高显著增加了肺腺癌 (LUAD) 的风险 (IVW:OR=1.484,p=0.003).
- 在单细胞计数和LUAD (IVW:OR=1.687,p<0.001) 之间确实存在因果关系.
- 单细胞计数成为导致LUAD风险增加的关键因素.
结论:
- 这项研究提供了证据表明,较高的白细胞总计数和增加的LUAD风险之间存在因果关系.
- 单细胞计数在增加肺腺癌风险方面发挥着重要作用.
- 对单细胞和LUAD之间关联的具体机制进行进一步的研究是有必要的.
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