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Updated: Jul 7, 2026

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工程脂肪细胞的植入抑制了癌症模型中的瘤进展

Hai P Nguyen1,2,3, Kelly An1,2, Yusuke Ito1,2

  • 1Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.

Nature biotechnology
|February 5, 2025
PubMed
概括

工程脂肪细胞 (脂肪细胞) 可以被修改为与瘤竞争营养,显著减缓癌症的进展. 这种新的脂肪操纵移植 (AMT) 方法在临床前模型和患者衍生器官中显示出前景.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...