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关于不同生物液体中的代谢学变化的潜在诊断价值的研究,用于吸入性肺炎

Lianghui Chen¹, Yazhen Chen¹, Fansen Lin¹

¹Department of Critical Care Medicine, Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, People's Republic of China.

BMC pulmonary medicine

|February 5, 2025

概括

像DHEAS和ADIOLS这样的新生物标志物显示出对诊断吸入性肺炎 (AP) 的希望. 这项代谢学研究可以改善这种肺炎的早期检测和患者的治疗结果.

科学领域:

生物化学生化学
临床诊断临床诊断临床诊断
代谢学代谢学代谢学

背景情况:

吸入性肺炎 (AP) 是由吸入物质引起的肺炎.
目前AP的诊断方法有局限性,导致误诊.
对于早期AP检测,需要可靠的生物标志物.

研究的目的:

为了确定新的生物标志物来诊断吸入性肺炎 (AP).
评估已识别的代谢物的诊断潜力.
探索AP中代谢组的临床实用性.

主要方法:

分析了使用LC-MS/MS的AP和非AP患者的生物液体 (BALF,唾液,血清,,尿液).
使用折叠变化,统计显著性和ROC曲线分析确定差异性代谢物.
与临床参数相关的关键代谢物,如APACHE II评分.

主要成果:

在AP和非AP组之间观察到显著的代谢差异.
确定了脱氨二硫酸 (DHEAS),安德罗二醇-3-硫酸 (ADIOLS) 和β-muricholic酸作为关键的生物标志物.
这些生物标志物显示出具有高AUC值和与临床严重性相关的诊断潜力.

结论:

DHEAS,ADIOLS和β-muricholic酸是AP诊断的有希望的生物标志物.
代谢学为开发AP的诊断工具提供了一种有价值的方法.
需要在更大的队列中进一步验证,以确认这些发现并探索潜在的机制.

关键词:

吸入性肺炎是什么意思生物标志物生物标志物液体染色学与双重质谱学一起进行.代谢特征代谢特征

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