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在神经母细胞瘤中,EDF1加速了氏体GD3的积累,以促进CD52-介导的CD8+T细胞功能障碍

Di Li1, Meng Li1, Zhenjian Zhuo1,2

  • 1Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China.

Journal of experimental & clinical cancer research : CR
|February 5, 2025
PubMed
概括

神经母细胞瘤 (NB) CD8+ T 细胞功能障碍与高EDF1表达有关,导致类酶-GD3积累和免疫抑制. 抑制EDF1可以通过恢复免疫功能来改善神经母细胞瘤治疗.

关键词:
CD8+ T 细胞功能障碍欧洲经济发展基金 (EDF1)在GD3中,GD3是指GD3.拉克的代谢过程神经母细胞瘤的神经母细胞瘤

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